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The two pathways are complementary, not redundant

4,44 Small fiber neuropathy (SFN) SFN primarily affects small unmyelinated C fibers and thinly myelinated A fibers, leading to disturbances in pain and temperature sensation

Most people start noticing improved clarity and brightness within 48 weeks of regular use

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Imbalances between glutamate and GABA, which are strongly implicated in neuropsychiatric disorders like MDD [77], can lead to excitotoxicity, whereby excessive glutamate activation of NMDARs and AMPARs triggers calcium overload, oxidative stress, and cell death [78]

Further clinical trials should be conducted to determine the beneficial effects of CoQ10 supplementation on migraine attacks